Cannabinoid CB1 receptor neutral antagonist AM4113 inhibits heroin self-administration without depressive side effects in rats

Cannabinoid receptor localization in brain.

Miles Herkenham, A B Lynn, M.D. Little et al. · Proceedings of the National Academy of Sciences · 1990 · 2.3K citations

Life Sciences, Neuroscience, Pharmacology +13

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

Luc F. Van Gaal, Aila Rissanen, André Scheen et al. · The Lancet · 2005 · 1.5K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Effect of Rimonabant, a Cannabinoid-1 Receptor Blocker, on Weight and Cardiometabolic Risk Factors in Overweight or Obese Patients

F. Xavier Pi‐Sunyer, Louis J. Aronne, Hassan Heshmati et al. · JAMA · 2006 · 1.2K citations

Medicine, Pharmacology, Pharmacotherapy +17

Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ ₁ Opioid Receptor Mechanism

Gianluigi Tanda, Francesco E. Pontieri, G. Di Chiara · Science · 1997 · 1.1K citations

Medicine, Neuroscience, Pharmacology +17

Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry

Pierre Mailleux, Jean‐Jacques Vanderhaeghen · Neuroscience · 1992 · 657 citations

Life Sciences, Neurobiology, Neuroscience +9