Concepedia

The Orotomide Olorofim Is Efficacious in an Experimental Model of Central Nervous System Coccidioidomycosis

Nathan P. Wiederhold, Laura K. Najvar, Rosie Jaramillo, Marcos Olivo, Michael Birch, Derek Law, John Rex, Gabriel Catano, Thomas F. Patterson

Antimicrobial Agents and Chemotherapy · 2018 · 78 citations · 18 references

DOIFull text

Open access

Concepts

Abstract

Olorofim (formerly F901318) is an advanced analog of the orotomide class that inhibits fungal pyrimidine biosynthesis. We evaluated the in vitro and in vivo activities of olorofim against Coccidioides species.

References

18

2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis

John N. Galgiani, Neil M. Ampel, Janis E. Blair et al. · Clinical Infectious Diseases · 2016 · 597 citations · Full text

, , +11

F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

Jason D. Oliver, Graham E. M. Sibley, Nicola Beckmann et al. · Proceedings of the National Academy of Sciences · 2016 · 282 citations · Full text

, , +17

Is It Ever Safe To Stop Azole Therapy for <i>Coccidioides immitis</i> Meningitis?

Daniel H. Dewsnup · Annals of Internal Medicine · 1996 · 205 citations

, , +10

Coccidioidomycosis in Renal Replacement Therapy

Irvin M. Cohen · Archives of Internal Medicine · 1982 · 160 citations

, , +17

The Natural History of Coccidioidal Meningitis: VA--Armed Forces Cooperative Studies, 1955-1958

T. Vincent, J N Galgiani, M. Huppert et al. · Clinical Infectious Diseases · 1993 · 118 citations

, , +9