Nickel‐Catalyzed Asymmetric [2+2] Cycloaddition Reaction of Hetero‐Bicyclic Alkenes with Internal Alkynes

Abstract

Abstract Enantioselective [2+2] cycloaddition reaction of azabenzonorbornadienes and oxabenzonorbornadienes with internal alkynes has been enabled by a catalyst system comprising Ni(COD) 2 and ( R )‐SIPHOS‐Ph‐Mor. This transformation represents the first asymmetric [2+2] cycloaddition reaction of azabenzonorbornadienes with internal alkynes, providing a straightforward method to prepare four‐membered carbocycles.