Concepedia

Synthesis and Anticancer Evaluation of 1,2,4-Oxadiazole Linked Imidazothiadiazole Derivatives

B. Chakrapani, V. Ramesh, G. Pourna Chander Rao, D. Ramachandran, T. Madhukar Reddy, A. Kalyan Chakravarthy, Gattu Sridhar

Russian Journal of General Chemistry · 2018 · 14 citations · 19 references

DOI

Concepts

Abstract

A series of 1,2,4-oxadiazole linked imidazothiadiazole derivatives 11a–11j have been synthesized. All derivatives were evaluated for anticancer activity against three human cancer cell lines (A375, MCF-7, and ACHN) and demonstrated activity comparable with that of doxorubicin. Three compounds 11b, 11c , and 11j exhibited higher anticancer activity than the positive control. The range of IC 50 for the compounds 11b, 11c , and 11j is determined to be from 0.11 to 2.98 μM.

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