Prevalence and antibiotics susceptibility patterns of carbapenem resistant Enterobacteriaceae

Abstract

Enterobacteriaceae is a family of Gram negative rods. However it natural habitat in the intestinal tract of humans and animals, but it has been implicated in many human diseases. The emergence of antimicrobial resistance among Enterobacteriaceae isolates has been increasingly reported worldwide and has become a major threat to the provision of healthcare. Carbapenems is beta-lactam antibiotics which is considered as a last line of therapy for multidrug resistant. The occurrence of carbapenem resistance among Enterobacteriaceae is a major health challenge which reduce the antibiotics choices that use to treat the infections which cause by these bacteria. This review was focused to increase our understanding about carbapenem resistance; and to display the size and extent of this problem base on up to day published works. The prevalence of carbapenem resistance Enterobacteriaceae (CRE) is slightly different among different countries, and their resistance rate for commonly uses antibiotics has been significantly detected. The use of combined antibiotics seem to be is only up to day known therapeutic choice. The major worrisome, treatment of the infections causes by these multidrugs resistant organisms is extremely difficult which may results in high mortality rates and healthcare costs. We need to focus on continues searching for other highly effective and low cost alternatives therapies.