Manganese dioxide nanoparticle induces Parkinson like neurobehavioral abnormalities in rats

Abstract

By considering that hippocampus plays an important role in cognitive function, behavioral abnormalities in intoxicated rats were predictable and nanoparticle administrated rats showed depression like behavioral signs dose dependently. Based on our results and previous studies that confirmed neurotoxicity of MnO2-NP in µg dose rang, the application of this nanoparticles should be limited and their waste should be neutralized before their release to the environment (Fig. 4, Ref. 31).