Bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma

Abstract

In the study, we disclose numerous novel genetic and epigenetic regulations and offer a vital molecular groundwork to understand the pathogenesis of HCC. Hub genes, including <i>PTGS2</i>, <i>PIK3CD</i>, <i>CXCL1</i>, <i>ESR1</i>, <i>MMP2</i>, <i>CDC45</i>, <i>DTL</i>, <i>AURKB</i>, <i>CDKN3</i>, <i>MCM2</i>, and <i>MCM10</i>, can be used as biomarkers based on aberrant methylation for the accurate diagnosis and treatment of HCC.