Concepedia

Publication | Open Access

Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis

DOIFull Paper Access

180

Citations

45

References

2018

Year

Madelon Paauwe, Mark J.A. Schoonderwoerd, Roxan F.C.P. Helderman, Tom J. Harryvan, Arwin Groenewoud, Gabi W. van Pelt, Rosalie Bor, Danielle M. Hemmer, Henri H. Versteeg, B. Ewa Snaar‐Jagalska,
Clinical Cancer Research

Abstract

Endoglin-expressing CAFs contribute to colorectal cancer progression and metastasis. TRC105 treatment inhibits CAF invasion and tumor metastasis, indicating an additional target beyond the angiogenic endothelium, possibly contributing to beneficial effects reported during clinical evaluations.<i>See related commentary by Becker and LeBleu, p. 6110</i>.

References

YearCitations

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