Concepedia

O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats

Rodrigo P. Silva‐Aguiar, Nathalia Cristina Ferreira Bezerra, Miguel C. Lucena, Gabriela Modenesi Sirtoli, Roberto T. Sudo, Gisele Zapata‐Sudo, Christina Maeda Takiya, Ana Acácia S. Pinheiro, Wagner B. Dias, Celso Caruso‐Neves

Journal of Biological Chemistry · 2018 · 54 citations · 32 references

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Concepts

Abstract

In conclusion, our results demonstrate a new mechanism involved in hypertension-associated proteinuria.

References

32

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

Xiaoyong Yang, Pat P. Ongusaha, Philip D.G. Miles et al. · Nature · 2008 · 598 citations

, , +12

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

Jeffrey R. Erickson, Laëtitia Pereira, Lianguo Wang et al. · Nature · 2013 · 595 citations

, , +12

Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy

Leileata M. Russo, Ruben M. Sandoval, Sílvia B. Campos et al. · Journal of the American Society of Nephrology · 2008 · 262 citations · Full text

, , +17

Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure

Ida G. Lunde, Jan Magnus Aronsen, Heidi Kvaløy et al. · Physiological Genomics · 2011 · 195 citations

, , +13

Regulation of Calcium/Calmodulin-dependent Kinase IV by O-GlcNAc Modification

Wagner B. Dias, Win D. Cheung, Zihao Wang et al. · Journal of Biological Chemistry · 2009 · 151 citations · Full text

, , +17