Concepedia

Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants

A. Fabre, Mónica Oleastro, Alexandra Nunes, Andrea Santos, Elodie Sifré, Astrid Ducournau, Lucie Bénéjat, Alice Buissonnière, Pauline Floch, Françis Mégraud,

Journal of Clinical Microbiology · 2018 · 41 citations · 44 references

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Abstract

A whole-genome sequencing (WGS) approach was conducted in order to identify the molecular determinants associated with antimicrobial resistance in 12 multidrug-resistant Campylobacter jejuni and Campylobacter coli isolates, with a focus on aminoglycoside resistance determinants. Two variants of a new aminoglycoside phosphotransferase gene [ aph ( 2 ″)- Ii 1 and aph ( 2 ″)- Ii 2 ] putatively associated with gentamicin resistance were found.

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