Melatonin Promotes Apoptosis of Colorectal Cancer Cells <i>via</i> Superoxide-mediated ER Stress by Inhibiting Cellular Prion Protein Expression

Abstract

Melatonin induces mitochondria-mediated cellular apoptosis in CRC cancer cells via a PrP^C-dependent pathway. PrP^C knockdown combined with melatonin amplifies the effects of melatonin, suggesting a novel therapeutic strategy in targeting CRC cells.