Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer

Abstract

The metabolic marker (PGK1/G6PD) is determined as the indicator for the biofunctional activity analysis of CTCs, compared with the existing morphological (EMT) classification on CTCs. The metabolic characterization of CTCs demonstrates that hypermetabolic GM⁺CTCs are promising biomarkers for prostate cancer metastasis.