Infection and Immunity · 2018 · 116 citations · 55 references
Veterinary MedicineImmunologyInfectious DiseasesImmunopathologyInflammationInnate ImmunityCytokine BiologyInflammasome ActivationInflammation In Infectious DiseaseInflammatory ProcessesInflammatory SignalingJoint InfectionsBrucella SpeciesCaspase-11 ActivationInflammasome Activation By BacteriaInflammasome RegulationInflammasome ResponsesInflammasome SignalingNlr Family Pyrin Domain-containing 3 InflammasomePyroptosis Mechanisms
Brucellosis, caused by the intracellular bacterial pathogen Brucella , is a zoonotic disease for which arthritis is the most common focal complication in humans. Here we investigated the role of inflammasomes and their effectors, including interleukin-1 (IL-1), IL-18, and pyroptosis, on inflammation and control of infection during Brucella -induced arthritis.
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