Neuromelanin‐sensitive magnetic resonance imaging features of the substantia nigra and locus coeruleus in <i>de novo</i> Parkinson's disease and its phenotypes

Abstract

Substantia nigra pars compacta neuromelanin changes occur across both motor and non-motor (with and without depressive symptoms) subtypes, whilst LC changes are more notable in PD patients with depressive symptoms. Our results may provide new evidence to understand the pathophysiology of non-motor symptoms in PD.