Construction of humanized anti-HER2 single-chain variable fragments (husFvs) and achievement of potent tumor suppression with the reconstituted husFv-Fdt-tBid immunoapoptotin

Humanization of an anti-p185HER2 antibody for human cancer therapy.

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

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Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

Leonard G. Presta, H Chen, Shane J. O'Connor et al. · PubMed · 1997 · 1.6K citations

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p185 <i> ^HER2 </i> Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

Robert M. Hudziak, Gail D. Lewis Phillips, Marcy Winget et al. · Molecular and Cellular Biology · 1989 · 663 citations · Full text

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Antibody framework residues affecting the conformation of the hypervariable loops

Jefferson Foote, Greg Winter · Journal of Molecular Biology · 1992 · 535 citations

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