Journal of Materials Chemistry B · 2018 · 59 citations · 48 references
MedicineImmunologyPharmacologyImmunopharmacologyInflammationRheumatologyAnti-inflammatory PharmacologyInflammatory ArthritisInflammatory MediatorsOxidative Stress In InflammationRheumatoid ArthritisSynovial InflammationAdjuvant NanoparticlesAnti-inflammatory NanomaterialsAnti-inflammatory Natural ProductsImmune Stress ResponseInflammatory Responses To NanoparticlesNanoparticlesOxidative Stress InflammationOxidative Stress Injury
in human neutrophils, stimulated by opsonized zymosan (OZ) and phorbol-12-myristate-13-acetate (PMA) was also suppressed. BG and its loaded NPs were revealed to antagonize the oxidative stress via interference with the NADPH oxidase metabolic pathway. Their anti-oxidant activity was further assessed by their inhibitory effect against TLR (TRL-2 & -4) and cytokine (IL-1β, IL-6 and TNF-α) production. The current investigation validates GX stabilized AgNPs as stable and promising multi-targeted therapeutic nano-cargo for BG delivery with efficient treatment of RA.
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Free radicals in biology and medicine
General Pharmacology The Vascular System · 1991 · 17.2K citations