BSA‐IrO₂: Catalase‐like Nanoparticles with High Photothermal Conversion Efficiency and a High X‐ray Absorption Coefficient for Anti‐inflammation and Antitumor Theranostics

Abstract

Intrinsically integrating precise diagnosis, effective therapy, and self-anti-inflammatory action into a single nanoparticle is attractive for tumor treatment and future clinical application, but still remains a great challenge. In this study, bovine serum albumin-iridium oxide nanoparticles (BSA-IrO₂ NPs) with extraordinary photothermal conversion efficiency, good photocatalytic activity, and a high X-ray absorption coefficient were prepared through one-step biomineralization. The nanoparticles allow tumor phototherapy and simultaneous photoacoustic/thermal imaging and computed tomography. More importantly, BSA-IrO₂ NPs can also act as a catalase to protect normal cells against H₂ O₂ -induced reactive oxygen pressure and inflammation while significantly enhancing photoacoustic imaging through microbubble-based inertial cavitation. These remarkable features may open up the exploration iridium-based nanomaterials in theranostics.