Concepedia

Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway

Tianxiao Gong, Liuqing Cui, Haili Wang, Haoxun Wang, Na Han

Journal of Translational Medicine · 2018 · 88 citations · 35 references

DOIFull text

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Abstract

KLF5 knockdown could suppress hypoxia-induced DDP resistance, and its mechanism may be due to the inhibition of HIF-1α-dependent glycolysis via inactivation of the PI3K/Akt/mTOR pathway.

References

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