Blood Advances · 2018 · 107 citations · 47 references
Life SciencesImmunologyMicrobiologyHost-pathogen InteractionsInflammationInnate ImmunityBacterial InfectionsBacterial PathogenesisInflammation In Infectious DiseaseNeutrophil BiologyPhagocyte BiologyAntimicrobial KillingBacteriostatic ActivityNeutrophil HeterogeneityNeutrophil InvolvementNeutrophil Responses To BacteriaPhagocyte Antimicrobial Activity
-banded neutrophils were the only neutrophil subset that adequately contained MRSA. These findings demonstrate a clear neutrophil heterogeneity in their antimicrobial capacity and the appearance of neutrophil subsets with a clear differentiation in functionality during acute inflammation. Furthermore, this study provides an evolutionary basis for the rapid release of banded neutrophils into the circulation during acute inflammation.
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Killing activity of neutrophils is mediated through activation of proteases by K+ flux
Emer P. Reeves, Hui Lu, Hugues Lortat Jacobs et al. · Nature · 2002 · 1.2K citations