Neurology · 2018 · 40 citations · 30 references
MedicineNeurologyNeuroscienceAgingDementiaNeurodegenerationAlzheimer DiseaseCognitive AgingCognitive DeclineCognitive ImpairmentDementia BiomarkersDementia Risk FactorsAlzheimer Disease DementiaAlzheimer Disease Vascular PathologyBiomarkersCardiovascular Risk MarkersCsf-to-blood Biomarker RatiosDementia-related Cognitive SymptomsTotal Tau ProteinVascular Dementia Biomarkers
OBJECTIVE: To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration. METHOD: ), total tau (t-tau), and phosphorylated tau (p-tau) in the association between CAIDE score and cognition. RESULTS: = 0.006). Analyses were adjusted for age, education, sex, premorbid intelligence, and stress. CONCLUSION: , WMH, and Alzheimer biomarkers.
30