Angewandte Chemie International Edition · 2018 · 95 citations · 30 references
PharmacyOncologyPharmacologyChemotherapyDrug DeliveryNanoparticle Drug DeliveryCancer NanomedicineGraphene NanomaterialsIntracellular Drug DeliveryNanocarriers For TherapeuticsNanomaterials For Drug DeliveryNanomedicineAdenosine Triphosphate ReleaseAnticancer ChemotherapyCancer NanotherapyCell InternalizationDrug Delivery NanocarriersGraphene-based MaterialsHyperthermiaSmart Drug Delivery Systems
Multidrug resistance (MDR), which leads tumors resistance to traditional anticancer drugs, can cause the failure of chemotherapy treatments. Herein, we present a new way to overcome this problem using smart multifunctional graphene-based drug delivery systems which can target subcellular organelles and show synergistic hyperthermia and chemotherapy. Mitochondria-targeting ligands are conjugated onto the doxorubicin-loaded, polyglycerol-covered nanographene sheets to actively accumulate them inside the mitochondria after charge-mediated cellular internalization. Upon near-infrared (NIR) irradiation, adenosine triphosphate (ATP) synthesis and mitochondrial function were inhibited and doxorubicin released into the cellular interior. The hyperthermia-accelerated drug release led to a highly selective anticancer efficiency, confirmed by in vitro and in vivo experiments.
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Kostya S. Novoselov, Vladimir I. Fal’ko, Luigi Colombo et al. · Nature · 2012 · 9.2K citations
Natural Sciences, Materials Engineering, Materials Science +9
Graphene in Mice: Ultrahigh In Vivo Tumor Uptake and Efficient Photothermal Therapy
Kai Yang, Shuai Zhang, Guoxin Zhang et al. · Nano Letters · 2010 · 2.4K citations