Oncology Letters · 2018 · 45 citations · 27 references
MedicineCancer BiologyOncologyGene ExpressionMolecular OncologyOncogenesMicrorna BiologyMicrorna-mediated RegulationMyc Family OncogenesOral CarcinogenesisOral Cavity CancerTumor Suppressor GenesCell Growth RegulationMicrorna Function In CancerMicrorna In CancerMicrorna ModulationMicrorna Regulation In CancerMicrorna-mediated OncogenesisOncogene RegulationTherapeutic Targeting Of Myc
Oral squamous cell carcinoma (OSCC) is the predominant histological type of oral cancer. The 5-year survival rate of OSCC is only ~50%. c-Myc is a known oncogene and target gene in various cancer types, including OSCC. The presnet study revealed that c-Myc is one of the target genes of miR-1294. Results indicated lower levels of miR-1294 in OSCC tissues samples collected from 24 patients with OSCC. Notably, overexpression of miR-1294 inhibited proliferation and migration in OSCC cell lines and inhibition of miR-1294 promoted cell growth and migration in OSCC cell lines. Moreover, miR-1294 can target the 3'UTR of c-Myc, as we identified a negative correlation between c-Myc mRNA expression and miR-1294 expression in 24 OSCC tissues. In conclusion, the data demonstrate the tumor suppressive role of miR-1294 in OSCC.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.6K citations
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
Nozomu Yanaihara, Natasha J. Caplen, Elise D. Bowman et al. · Cancer Cell · 2006 · 3K citations · Full text