Blood · 2018 · 55 citations · 50 references
Life SciencesGeneticsHematologyApoptosisNeoplasiaStem Cell BiologyHematopoietic DevelopmentHematopoietic DifferentiationHematopoietic Stem Cell BiologyHematopoietic Stem CellsMyelodysplastic SyndromesMyeloproliferative NeoplasmsHematopoietic Lineage SpecificationHematopoietic SignalingHematopoietic Stem Cell Epigenetic RegulationHematopoietic Stem Cell Signaling PathwaysHematopoietic Stem Cell Transcriptional Regulation
Key Points Srsf2 P95H/+ mutation within hemopoietic stem cells is required to initiate myeloid-biased hemopoiesis. Mutation of Srsf2 is sufficient to initiate the development of MDS/MPN in vivo in the setting of native hemopoiesis.
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voom: precision weights unlock linear model analysis tools for RNA-seq read counts
Charity W. Law, Yunshun Chen, Wei Shi et al. · Genome biology · 2014 · 6.7K citations · Full text
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
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Life Sciences, Genetics, Hematology +17