Antifungal piperamides from Piper mollicomum Kunth (Piperaceae)

Abstract

The phytochemical study on dichlorometane extracts of leaves, stem and roots of Piper mollicomum Kunth (Piperaceae) led to isolation of the known piperamides tembamide (1), (R)-(-)-tembamide acetate (2) and riparin I (3). Compounds 1 and 2 displayed moderate in vitro antifungal activity against Cladosporium cladosporioides (5.0 μg) and Cladosporium sphaerospermum (1.0 μg) by direct bioautographic analyses and compound 3 was inactive up to 100.0 μg.