Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and – pyrimidines

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

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Medicine, Oncology, Pharmacology +16

Studies on neplanocin a, new antitumor antibiotic. I. Producing organism, isolation and characterization.

Satoshi Yaginuma, Naoki Muto, Masatoshi Tsujino et al. · The Journal of Antibiotics · 1981 · 262 citations · Full text

Life Sciences, Microbiology, Drug Discovery +5

4-(1,2,4-Triazol-1-yl)- and 4-(3-nitro-1,2,4-triazol-1-yl)-1-(β-<scp>D</scp>-2,3,5-tri-O-acetylarabinofuranosyl)pyrimidin-2(1H)-ones. Valuable intermediates in the synthesis of derivatives of 1-(β-<scp>D</scp>-arabinofuranosyl)cytosine (ara-C)

K. J. DIVAKAR, Colin B. Reese · Journal of the Chemical Society Perkin Transactions 1 · 1982 · 163 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Synthesis of Diastereomerically Pure Nucleotide Phosphoramidates

Bruce S. Ross, P. Ganapati Reddy, Hai‐Ren Zhang et al. · The Journal of Organic Chemistry · 2011 · 148 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Biological methylation and drug design

GE Powell · FEBS Letters · 1987 · 123 citations

Pharmacy, Biochemistry, Medicinal Chemistry +12