Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt Rd, Aurélie Bertin, M Jalfre · PubMed · 1977 · 3.3K citations

Depressed State, Psychopharmacology, Mental Health +19

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Nanxin Li, Boyoung Lee, Rongjian Liu et al. · Science · 2010 · 2.8K citations · Full text

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

Anita E. Autry, Megumi Adachi, E. D. Nosyreva et al. · Nature · 2011 · 1.9K citations

Psychiatry, Mood Symptom, Addiction +13

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide

Tiziana Bisogno, L Hanŭs, Luciano De Petrocellis et al. · British Journal of Pharmacology · 2001 · 1.3K citations · Full text

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

Nanxin Li, Rong-Jian Liu, Jason M. Dwyer et al. · Biological Psychiatry · 2011 · 1.1K citations

Stress Hormone, Psychiatry, Behavioral Neuroscience +15