Sulfonimidates: Useful Synthetic Intermediates for Sulfoximine Synthesis via C–S Bond Formation

Abstract

Medicinally relevant sulfoximines are accessed from C-S coupling of sulfonimidates and commercially available organomagnesium reagents. Sulfonimidates are conveniently synthesized by oxidative alkoxylation of readily available sulfinamides. This constitutes a general C-S coupling approach for the synthesis of sulfoximines.