Warfarin, but not rivaroxaban, promotes the calcification of the aortic valve in ApoE−/− mice

Abstract

We showed that warfarin, but not rivaroxaban, could induce calcific valve degeneration in a mouse model of atherosclerosis. Both the treatments did not significantly affect the progression of atherosclerosis. Overall, these data suggest a safer profile of rivaroxaban on the risk of cardiovascular disease progression.