Cholesterol is the main regulator of the carbon dioxide permeability of biological membranes

Abstract

We present here a compilation of membrane CO₂ permeabilities (Pco₂) for various cell types from the literature. Pco₂ values vary over more than two orders of magnitude. Relating Pco₂ to the cholesterol content of the membranes shows that, with the exception of red blood cells, it is essentially membrane cholesterol that determines the value of Pco₂. Thus, the observed strong modulation of Pco₂ in the majority of membranes is caused by cholesterol rather than gas channels.