The Journal of Organic Chemistry · 2018 · 42 citations · 60 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCatalyst DesignCatalyst PreparationCatalyst SynthesisHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisHeterocycle FunctionalizationLigand DesignMild Reaction ConditionsPalladium CatalystsTransition Metal-catalyzed SynthesisTransition-metal-catalyzed Functionalization
Rationally designed fluorene-based mono- and bimetallic Pd-PEPPSI complexes were synthesized and demonstrated to be effective for the one-pot sequential α-arylation/alkylation of oxindoles. This streamlined approach offers efficient access to functionalized 3,3-disubstituted oxindoles in excellent yields (up to 89%) under mild reaction conditions.
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An overview of N-heterocyclic carbenes
Matthew N. Hopkinson, Christian Richter, Michael Schedler et al. · Nature · 2014 · 4.2K citations