An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders

The Protein Data Bank

Helen M. Berman · Nucleic Acids Research · 2000 · 38.9K citations

Biological Database, Biochemistry, Structural Bioinformatics +12

Analysis of protein-coding genetic variation in 60,706 humans

Monkol Lek, Konrad J. Karczewski, Eric Vallabh Minikel et al. · Nature · 2016 · 10.1K citations · Full text

Phenotypic Variation, Protein-coding Genetic Variation, Genetics +5

Error and attack tolerance of complex networks

Nature · 2000 · 7K citations · Full text

Engineering, Network Science, Network Complexity +5

A general framework for estimating the relative pathogenicity of human genetic variants

Martin Kircher, Daniela Witten, Preti Jain et al. · Nature Genetics · 2014 · 6.4K citations · Full text

Relative Pathogenicity, Genetics, Genetic Epidemiology +16

The Pfam protein families database: towards a more sustainable future

ROBERT FINN, Penelope Coggill, Ruth Y. Eberhardt et al. · Nucleic Acids Research · 2015 · 6.3K citations · Full text

Structural Bioinformatics, Genetics, Molecular Biology +22