Asperfurandiones A and B, two antifungal furandione analogs from a marine-derived fungus <i>Aspergillus versicolor</i>

Abstract

Two new furandione derivatives, designated as asperfurandiones A (<b>1</b>) and B (<b>2</b>), were isolated from the solid culture of the marine-derived fungus <i>Aspergillus versicolor</i>. Their structures were elucidated using a combination of mass spectrometry and NMR spectroscopy. Additionally, asperfurandiones A and B both showed moderate antifungal activity against <i>Gaeumannomyces graminis</i>, <i>Cryptococcus neoformans</i>, and <i>Candida albicans</i> with MIC values of 64 μg/mL.