Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

Abstract

These results suggest that vascular adenosine A_2A (and, to a certain extent, also A₁) receptors mediate the CGS21680-induced meningeal vasodilation. These receptors do not appear to modulate prejunctionally the sensory release of CGRP. Prevention of meningeal arterial dilation might be predictive for anti-migraine drugs, and since none of these JNJ antagonists modified per se blood pressure, selective A_2A receptor antagonism may offer a novel approach to antimigraine therapy which remains to be investigated in clinical trials.