Understanding Context Dependence in Glucocorticoid–Fitness Relationships: The Role of the Nature of the Challenge, the Intensity and Frequency of Stressors, and Life History

Abstract

It has been well-established that there is variation in the strength and direction of the relationship between circulating glucocorticoids (GCs) and fitness. When studies demonstrate such variation or the direction of the GC-fitness relationship is unexpected, the results are often attributed to context-dependency. However, descriptors of context can be vague (e.g., "environmental context") and few studies explicitly test how the optimal hypothalamic-pituitary-adrenal (HPA) axis response to stressors varies across specific contexts. Although existing hypotheses create a strong foundation for understanding GC-fitness relationships, many do not provide explicit predictions of how, when, and why the relationships will change. Here, we discuss three broad factors which we expect to shape the relationships between HPA axis activity and fitness metrics: (1) whether the HPA axis-mediated response matches the challenge, (2) the intensity and frequency of challenges, and (3) life history. We also make predictions for how these factors might affect GC-fitness relationships and discuss ways to test these predictions. Observational studies, experimental manipulations of context, and large-scale cross-species comparisons will be critical to understanding the observed variation in GC-fitness relationships.