Concepedia

Caspofungin dosage adjustments are not required for patients with Child–Pugh B or C cirrhosis

Thierry Gustot, Rob ter Heine, Elisa Brauns, Frédéric Cotton, Frédérique Jacobs, Roger J. M. Brüggemann

Journal of Antimicrobial Chemotherapy · 2018 · 19 citations · 12 references

DOIFull text

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Abstract

In contrast to the product information, we recommend giving the full dose of caspofungin regardless of the presence and severity of cirrhosis to avoid a subtherapeutic exposure.

References

12

Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

Peter G. Pappas, Carol A. Kauffman, David R. Andes et al. · Clinical Infectious Diseases · 2015 · 3.9K citations · Full text

Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose

RJ Keizer, MO Karlsson, Andrew C. Hooker · CPT Pharmacometrics & Systems Pharmacology · 2013 · 640 citations · Full text

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Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resampling

Anne‐Gaëlle Dosne, Martin Bergstrand, Kajsa Harling et al. · Journal of Pharmacokinetics and Pharmacodynamics · 2016 · 245 citations · Full text

<i>In Vivo</i> Comparison of the Pharmacodynamic Targets for Echinocandin Drugs against <i>Candida</i> Species

David R. Andes, Daniel J. Diekema, Michael A. Pfaller et al. · Antimicrobial Agents and Chemotherapy · 2010 · 225 citations · Full text

, , +20

Disposition of Caspofungin: Role of Distribution in Determining Pharmacokinetics in Plasma

Julie A. Stone, Xin Xu, Gregory A. Winchell et al. · Antimicrobial Agents and Chemotherapy · 2004 · 137 citations · Full text

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