Concepedia

Sensitivity of Single-Molecule Array Assays for Detection of Clostridium difficile Toxins in Comparison to Conventional Laboratory Testing Algorithms

Alice Banz, Aude Lantz, Brigitte Riou, Agnès Foussadier, Mark A. Miller, Kerrie Davies, Mark H. Wilcox

Journal of Clinical Microbiology · 2018 · 28 citations · 16 references

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Concepts

Abstract

Guidelines recommend the use of an algorithm for the laboratory diagnosis of Clostridium difficile infection (CDI). Enzyme immunoassays (EIAs) detecting C. difficile toxins cannot be used as standalone tests due to suboptimal sensitivity, and molecular tests suffer from nonspecificity by detecting colonization.

References

16

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

L. Clifford McDonald, Dale N. Gerding, Stuart Johnson et al. · Clinical Infectious Diseases · 2017 · 2.7K citations · Full text

, , +16

Nosocomial Acquisition of<i>Clostridium difficile</i>Infection

Lynne V. McFarland, Maury E. Mulligan, R Y Kwok et al. · New England Journal of Medicine · 1989 · 1.4K citations

, , +13

European Society of Clinical Microbiology and Infectious Diseases: Update of the Treatment Guidance Document for Clostridium difficile Infection

S. B. Debast, Martijn P. Bauer, Ed J. Kuijper · Clinical Microbiology and Infection · 2013 · 1.2K citations · Full text

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European Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile infection

Monique J. T. Crobach, Tim Planche, Catherine Eckert et al. · Clinical Microbiology and Infection · 2016 · 588 citations · Full text

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Overdiagnosis of <i>Clostridium difficile</i> Infection in the Molecular Test Era

Christopher R. Polage, Clare E. Gyorke, Michael A. Kennedy et al. · JAMA Internal Medicine · 2015 · 578 citations

, , +15