Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation

Abstract

Key Points Shear-induced, Gα13-mediated integrin outside-in signaling facilitates platelet PS exposure, MV release, and coagulation. An inhibitor of outside-in signaling inhibits not only occlusive platelet thrombus formation but also intravascular coagulation in vivo.