Concepedia

<i>In Vitro</i> and <i>In Vivo</i> Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus

Karen Joy Shaw, Wiley A. Schell, Jonathan A. Covel, Gisele Duboc, Charles Giamberardino, Mili Kapoor, Molly Moloney, Quinlyn A. Soltow, Jennifer L. Tenor, Dena L. Toffaletti,

Antimicrobial Agents and Chemotherapy · 2018 · 120 citations · 32 references

DOIFull text

Open access

Concepts

Abstract

CFU/g brain tissue, representing the nearly complete or complete sterilization of lung and brain tissue at the higher doses. These data support the further clinical evaluation of this new class of antifungal agents for the treatment of CM.

References

32

Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America

John R. Perfect, William E. Dismukes, Françoise Dromer et al. · Clinical Infectious Diseases · 2010 · 2.7K citations · Full text

, , +15

Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

Radha Rajasingham, Rachel M. Smith, Benjamin J. Park et al. · The Lancet Infectious Diseases · 2017 · 1.9K citations · Full text

, , +16

Guide for the Care and Use of Laboratory Animals (8th edn)

Udo Albus · Laboratory Animals · 2012 · 1.7K citations · Full text

, , +9

Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

Síle F. Molloy, Cecilia Kanyama, Robert S. Heyderman et al. · New England Journal of Medicine · 2018 · 405 citations · Full text

, , +17

Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole

Tihana Bicanic, Graeme Meintjes, Robin Wood et al. · Clinical Infectious Diseases · 2007 · 276 citations · Full text

, , +17