Blood · 2018 · 45 citations · 44 references
Life SciencesImmunologyMolecular BiologyCellular ImmunologyImmunopathologyImmunoregulationEffector T Cell FunctionRegulatory T Cell DysfunctionRegulatory T CellsT Cell ActivationT Cell BiologyT Cell DifferentiationCd8 Positive T Cell ResponsesCd8 Positive T CellsCd8 T Cell ActivationPeripheral Regulatory T CellsRegulatory T Cell Suppressive FunctionT-cell RegulationTreg Cell Homeostasis
Key Points CD8+ Tregs possess a proapoptotic phenotype when compared with CD4+ Tregs, which is characterized by an inversion of the Bim/Mcl-1 ratio. Absence of Bim in adoptively transferred CD8+ Tregs results in augmented in vivo survival and superior protection from GVHD.
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Lou Jost · Oikos · 2006 · 4.6K citations
Life Sciences, Ecology, Biogeography +14
WanJun Chen, Wenwen Jin, Neil J. Hardegen et al. · The Journal of Experimental Medicine · 2003 · 4.6K citations · Full text
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
Jason D. Fontenot, Jeffrey P. Rasmussen, Luke M. Williams et al. · Immunity · 2005 · 2.2K citations · Full text