Concepedia

RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice

Samuel Y. Ng, Leon Brown, Kristen E. Stevenson, Tiffany DeSouza, Jon C. Aster, Abner Louissaint, David M. Weinstock

Blood · 2018 · 121 citations · 51 references

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Abstract

Key Points Expression of RhoA G17V in CD4+ cells results in cellular and humoral autoimmunity. RhoA G17V expression with Tet2 loss induces T-cell lymphomas with features of AITL.

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