Th2 cytokines orchestrate the secretion of <scp>MUC</scp>5<scp>AC</scp> and <scp>MUC</scp>5B in <scp>IL</scp>‐5‐positive chronic rhinosinusitis with nasal polyps

Abstract

In type-2 inflammatory nasal polyps, characterized by the tissue expression of IL-5, MUC5AC and MUC5B are overexpressed. Both IL-4 and IL-13 may upregulate mucin expression via IL-4Rα, which is also overexpressed in IL-5(+) CRSwNP.