Rhodium-catalyzed C–H functionalization of heteroarenes using indoleBX hypervalent iodine reagents

Abstract

The C-H indolation of heteroarenes was realized using the benziodoxolone hypervalent iodine reagents indoleBXs. Functionalization of the C-H bond in bipyridinones and quinoline <i>N</i>-oxides catalyzed by a rhodium complex allowed to incorporate indole rings into aza-heteroaromatic compounds. These new transformations displayed complete regioselectivity for the C-6 position of bipyridinones and the C-8 position of quinoline <i>N</i>-oxides and tolerated a broad range of functionalities, such as halogens, ethers, or trifluoromethyl groups.