Journal of Child Neurology · 2018 · 74 citations · 9 references
Pain DisordersComplex Motor DisorderCannabinoid PharmacologyCannabis LegalizationAddiction MedicinePain ManagementNeurologyPsychoactive Substance UseNeuropathologyMotor DisorderHealth SciencesCannabis UseMedical CannabisPsychoactive DrugPsychiatryBehavioral PharmacologyNeuropharmacologyMovement DisordersCannabisSubstance AbuseAddictionPediatricsAbnormal MovementsMood DisordersStereotypic Movement DisorderMedicine
A complex motor disorder is a combination of various types of abnormal movements that are associated with impaired quality of life (QOL). Current therapeutic options are limited. We studied the efficacy, safety, and tolerability of medical cannabis in children with complex motor disorder. This pilot study was approved by the institutional ethics committee. Two products of cannabidiol (CBD) enriched 5% oil formulation of cannabis were compared: one with 0.25% δ-9-tetrahydrocannabinol (THC) 20:1 group, the other with 0.83% THC 6:1 group. Patients aged 1 to 17 years (n = 25) with complex motor disorder were enrolled. The assigned medication was administered for 5 months. Significant improvement in spasticity and dystonia, sleep difficulties, pain severity, and QOL was observed in the total study cohort, regardless of treatment assignment. Adverse effects were rare and included worsening of seizures in 2 patients, behavioral changes in 2 and somnolence in 1.
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Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
Orrin Devinsky, J. Helen Cross, Linda Laux et al. · New England Journal of Medicine · 2017 · 1.6K citations · Full text
John T. Farrar, Andrea B. Troxel, Colin Stott et al. · Clinical Therapeutics · 2008 · 256 citations
Reliability, Neuromuscular Coordination, Attention Control +8