IgG1⁺ B‐cell immunity predates IgE responses in epicutaneous sensitization to foods

Abstract

Our data demonstrate that IgG1⁺ B-cell immunity against food allergens in epicutaneous sensitization precedes the generation of IgE responses. Therefore, the assessment of allergen-specific cellular and humoral IgG1⁺ immunity may help to identify individuals at risk of developing IgE-mediated food allergy and hence provide a window for therapeutic interventions.