Epigenetic dysregulation of<i>TET2</i>in human glioblastoma

Abstract

Ten-eleven translocation (TET) enzymes are frequently deregulated in cancer, but the underlying molecular mechanisms are still poorly understood. Here we report that <i>TET2</i> shows frequent epigenetic alterations in human glioblastoma including DNA hypermethylation and hypo-hydroxymethylation, as well as loss of histone acetylation. Ectopic overexpression of <i>TET2</i> regulated neural differentiation in glioblastoma cell lines and impaired tumor growth. Our results suggest that epigenetic dysregulation of <i>TET2</i> plays a role in human glioblastoma.