Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ - Concepedia

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Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ

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References

2018

Year

Pu Wang, Yucheng Lu, Jie Wang, Lan Wang, Hanry Yu, Yuan Fei Li, Alice P.S. Kong, Juliana C.N. Chan, Shaochin Lee

Cellular Physiology and Biochemistry

Abstract

Our results show that type 2 diabetes promotes cell centrosome amplification, and suggest that the diabetic pathophysiological factors-activated AKT-ROS-dependent signalling of ROCK1 and 14-3-3σ is the underlying molecular mechanism.