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Effect of Interleukin-1 Blockade on Left Ventricular Systolic Performance and Work: A Post Hoc Pooled Analysis of 2 Clinical Trials

Leo F. Buckley, Salvatore Carbone, Cory R. Trankle, Justin M. Canada, Claudia Oddi Erdle, Jessica A. Regan, Michele Mattia Viscusi, Dinesh Kadariya, Hayley Billingsley, Ross Arena,

Journal of Cardiovascular Pharmacology · 2018 · 28 citations · 9 references

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Abstract

In this post hoc analysis, LVEes and LVEF increased significantly in patients treated with an IL-1 blocker but not in placebo-treated patients. An effect of IL-1 blockade on calculated PVA was not detected.

References

9

Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction

Theophilus Owan, David O. Hodge, Regina M. Herges et al. · New England Journal of Medicine · 2006 · 4.2K citations

Load Independence of the Instantaneous Pressure-Volume Ratio of the Canine Left Ventricle and Effects of Epinephrine and Heart Rate on the Ratio

Hiroyuki Suga, K Sagawa, Artin A. Shoukas · Circulation Research · 1973 · 1.5K citations

, , +20

Total mechanical energy of a ventricle model and cardiac oxygen consumption

Hiroyuki Suga · American Journal of Physiology-Heart and Circulatory Physiology · 1979 · 429 citations

, , +17

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

Gustavo Monnerat, Micaela López Alarcón, Luiz Ricardo C. Vasconcellos et al. · Nature Communications · 2016 · 263 citations · Full text

Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure

Benjamín W. Van Tassell, Justin M. Canada, Salvatore Carbone et al. · Circulation Heart Failure · 2017 · 232 citations · Full text