Peptide SA12 inhibits proliferation of breast cancer cell lines MCF-7 and MDA-MB-231 through G0/G1 phase cell-cycle arrest

Abstract

We concluded that SA-12 inhibits the proliferation of MCF-7 and MDA-MB-231 cells through G0/G1 cell cycle arrest. Cell cycle related genes <i>cyclin D1</i>, <i>CDK4</i>, and <i>p16</i> participate in the process, and MECP2 is essential for the enhanced expression of <i>p16</i> gene induced by SA-12.