P2Y12 antagonist ticagrelor inhibits the release of procoagulant extracellular vesicles from activated platelets

Abstract

Inhibition of P2Y1 and P2Y12 receptors reduces platelet aggregation and affects the release of distinct subpopulations of PEVs. Ticagrelor decreases the release of procoagulant PEVs from activated platelets, which may contribute to the observed clinical benefits in patients treated with ticagrelor.