Concepedia

A defect in KCa3.1 channel activity limits the ability of CD8 <sup>+</sup> T cells from cancer patients to infiltrate an adenosine-rich microenvironment

Ameet A. Chimote, András Balajthy, Michael J. Arnold, Hannah S. Newton, Péter Hajdú, Julianne Qualtieri, Trisha M. Wise‐Draper, Laura Conforti

Science Signaling · 2018 · 69 citations · 36 references

DOI

Concepts

Abstract

T cells to adenosine and the potential therapeutic benefit of KCa3.1 channel activators, which could increase infiltration of these T cells into tumors.

References

36

A2A adenosine receptor protects tumors from antitumor T cells

Akio Ohta, Elieser Gorelik, Simon J. Prasad et al. · Proceedings of the National Academy of Sciences · 2006 · 1K citations

, , +16

Purinergic Signaling during Inflammation

Holger K. Eltzschig, Michail V. Sitkovsky, Simon C. Robson · New England Journal of Medicine · 2012 · 698 citations

, , +14

Ionic immune suppression within the tumour microenvironment limits T cell effector function

Robert Eil, Suman K. Vodnala, David Clever et al. · Nature · 2016 · 683 citations · Full text

, , +12

Design of a potent and selective inhibitor of the intermediate-conductance Ca <sup>2+</sup> -activated K <sup>+</sup> channel, <i>IKCa1</i> : A potential immunosuppressant

Heike Wulff, Mark J. Miller, Wolfram Hänsel et al. · Proceedings of the National Academy of Sciences · 2000 · 606 citations · Full text

, , +13

Immunological mechanisms of the antitumor effects of supplemental oxygenation

Stephen Hatfield, Dmitriy Lukashev, Taylor H. Schreiber et al. · Science Translational Medicine · 2015 · 596 citations

, , +17